FTase - H-RAS-1 (CVLS) MAIN INTERACTIONS
- Electrostatic and coordination
interaction between zinc ion and C-term carboxyl group.
- The N-term ammonic group is inserted
in a pocket lined by aromatic residues (Tyr-361B
and Trp-106B). Obviously, this interaction is
not present in natural complex FTase-H-RAS-1, but it's
interesting to perform a comparison with RAS-mimetic
- Electrostatic interaction between
Lys-164A and carbonyl group.
H-RAS-1 disposition in the ternary complex.
See the main
interactions between FTase and FPP.